Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer
Our study showed that CTL and NK cell-associated gene expression and protein levels differ significantly according to TIL levels and that CTL-NK score and distribution of TILs within tumors have a prognostic value. These findings emphasize the importance of CTLs and NK cells as well as the spatial uniformity of TIL infiltration in clinical outcome of TNBC patients, providing valuable insights for refining prognostic assessments and guiding immunotherapeutic strategies.
Authors
- Koung Jin Suh (ORCID: https://orcid.org/0000-0002-1881-8738)
- Hyun Jung Kwon (ORCID: https://orcid.org/0000-0001-8822-7899)
- Yul Ri Chung (ORCID: https://orcid.org/0000-0001-9501-8657)
- Se Hyun Kim (ORCID: https://orcid.org/0000-0002-2292-906X)
- Eunkyung Han (ORCID: https://orcid.org/0000-0003-1697-3336)
- Hee-Chul Shin (ORCID: https://orcid.org/0000-0001-6096-0845)
- Jee Hyun Kim (ORCID: https://orcid.org/0000-0003-1336-3620)
- So Yeon Park (ORCID: https://orcid.org/0000-0002-0299-7268)
- Eun-Kyu Kim
- Hye Yeon Choi
Institutions
- Seoul National University Bundang Hospital (KR)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1186/s13058-024-01932-4
- Citations
- 13
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- Seoul National University Bundang Hospital
- National Research Foundation
- Seoul National University
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea