Antioxidant system of the liver of male rats at different stages of ontogenesis under conditions of chronic exposure to low-intensity electromagnetic field

Currently, the World Health Organization (WHO) recognizes that radio frequency electromagnetic fields (RF EMF) are one of the most common sources of electromagnetic radiation and are significant factors for human health, having a pronounced biological effect. In addition, oxidative stress caused by hyperproduction of free radicals due to exposure to RF EMF is a factor that provokes the development of many diseases and, in particular, liver pathologies, including in the elderly.For the first time, studies were conducted on the state of the antioxidant system of the liver of male rats at various stages of postnatal development (young, adult, aging and pre-senile periods) under conditions of chronic exposure to EMF from a Wi-Fi device (2,45 GHz, PD=0,79±0,52 μW/cm2, 24 h/day, daily) from the age of 50 days until they reach 24 months. In the cytosolic-microsomal fraction, the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase was determined by spectrophotometry, and in the tissue homogenate, the concentration of protein-bound glutathione, sulfhydryl groups of proteins, total SH groups, reduced glutathione and protein oxidation products was determined.The revealed changes in the state of the liver antioxidant system during chronic exposure to EMF from Wi-Fi equipment on the body during aging indicate activation of the glutathionedependent system in experimental animals. The revealed changes are manifested in maintaining a stably elevated level of the reduced form of thiols in the liver tissue and are an adaptive response of cells to prolonged exposure of the body to EMF from Wi-Fi equipment.