May Nesfatin-1 is a New Marker of Inflammation in Varicose Veins?

Objective: The expression of nesfatin-1, an anti-inflammatory peptide, in varicose saphenous veins, may indicate the inflammation process in these veins. For this purpose, we aimed to determine the presence nesfatin-1 in varicose veins. Materials and methods: In this study, varicose vein samples have been taken from 50 patients with varicose veins. For the control group, vena saphena magna tissue samples taken out for coronary bypass were obtained from 50 patients. Immunohistochemical staining was performed by staining tissues with nesfatin-1 antibody and two groups were compared. Results: In the immunostaining of nesfatin-1 on varicose vein samples, 38 (76%) patients were determined to be positive, and no staining was observed in 12 (24%) patients. In saphenous tissue samples taken from the control group, 10 samples (20%) were stained positive with nesfatin immunostaining, while 40 samples (80%) were not stained. Staining of varicose veins with nesfatin immunostaining showed a statistically significant difference compared to the staining of samples taken from the control group (p<0.0001). Conclusion: When compared to healthy veins, it was demonstrated that the varicose etiopathogenesis. It is concluded that the expression of nesfatin-1, which is an anti-inflammatory peptide, in varicose veins may be a response to the inflammatory process.