<scp>L</scp><scp>XR</scp> regulation of adipose tissue inflammation during obesity is associated with dysregulated macrophage function
Our study highlights distinct roles for each LXR isoform in AT inflammation regulation, with LXRβ being crucial for maintaining the anti- and proinflammatory balance in ATMs. Thus, LXRβ holds therapeutic potential as a target to treat AT inflammation and insulin resistance.
Authors
- Alexandre S. Basso (ORCID: https://orcid.org/0000-0002-3302-4792)
- Felippe Mousovich‐Neto (ORCID: https://orcid.org/0000-0002-8245-9450)
- Gisele Castro (ORCID: https://orcid.org/0000-0001-9965-5485)
- Ronaldo C. Araújo (ORCID: https://orcid.org/0000-0003-0095-4608)
- João Victor Virgílio-da-Silva (ORCID: https://orcid.org/0000-0002-7846-7386)
- Marcelo A. Mori (ORCID: https://orcid.org/0000-0001-7112-5263)
- Diorge Paulo de Souza (ORCID: https://orcid.org/0000-0003-1303-1765)
- Gustavo Gastão Davanzo (ORCID: https://orcid.org/0000-0002-6723-1933)
- Luz Aurora Pimentel
- Gerson S. Profeta (ORCID: https://orcid.org/0000-0001-6394-2263)
- Juliana Silveira Prodonoff (ORCID: https://orcid.org/0000-0003-1158-6441)
- Marcia Grando Guereschi (ORCID: https://orcid.org/0009-0002-4618-5998)
- Niels Olsen Saraiva Câmara (ORCID: https://orcid.org/0000-0001-5436-1248)
- Cristiane Naffah de Souza Breda (ORCID: https://orcid.org/0000-0002-9631-1932)
- Pedro M. Moraes‐Vieira (ORCID: https://orcid.org/0000-0002-8263-786X)
- Jéssica Aparecida da Silva Pereira (ORCID: https://orcid.org/0000-0002-8503-1732)
- Cristhiane Fávero de Aguiar (ORCID: https://orcid.org/0000-0003-3584-9541)
Institutions
- Joslin Diabetes Center (US)
- Harvard University (US)
- MRC Laboratory of Molecular Biology (GB)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade Federal de São Paulo (BR)
- Medical Research Council (GB)
Publication Details
- Journal
- Obesity
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/oby.24158
- Citations
- 8
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico