In‐Source Collision‐Induced Dissociation (CID) Improves Higher‐Energy Collisional Dissociation (HCD)‐Dependent Fragmentation of ADP‐Ribosyl Peptides
In-source CID converts ADP-ribosyl to phosphoribosyl-H<sub>2</sub>O peptides that are more amenable to HCD-dependent peptide sequencing, providing an alternative method for acceptor site determination when ETD-based methods are not available.
Authors
- Sasha A. Singh (ORCID: https://orcid.org/0000-0003-0929-3164)
- Masanori Aikawa (ORCID: https://orcid.org/0000-0002-9275-2079)
- Taku Kasai (ORCID: https://orcid.org/0000-0002-8075-6099)
- Yuto Nakamura (ORCID: https://orcid.org/0009-0001-7909-8674)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/rcm.9961
- Citations
- 2
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Kowa Company
- National Heart, Lung, and Blood Institute