Preventing epileptogenesis by interaction between inositol isomers and proteins
Epilepsy is a common neurological disorder characterized by spontaneous recurrent seizures and a range of associated comorbidities. The process that leads to the development of epilepsy is called epileptogenesis, and currently, no medication can effectively prevent it. Our study investigated the effects of a group of compounds-myo-inositol, scyllo-inositol, and D-chiro-inositol-that have potential antiepileptogenic properties on epilepsy induced by kainic acid. We found that: (i) the three inositol isomers share some common target proteins and also have unique ones and (ii) all of them counteract epileptogenesis and the related cognitive impairments.
Authors
- Vincenzo Lagani (ORCID: https://orcid.org/0000-0002-6552-6076)
- Tamar Kiguradze
- Revaz Solomonia (ORCID: https://orcid.org/0000-0003-4798-6762)
- Mérab Kokaia (ORCID: https://orcid.org/0000-0001-7984-3921)
- Lia Tsverava (ORCID: https://orcid.org/0000-0001-5545-8009)
- Giorgi Gamkrelidze
- Luka Kharkhelauri
- Veriko Bokuchava (ORCID: https://orcid.org/0009-0002-3092-1356)
Institutions
- Ilia State University (GE)
- Lund University (SE)
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/epi4.13061
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Science Foundation
- Svenska Forskningsrådet Formas
- Shota Rustaveli National Science Foundation
- Norges Forskningsråd