On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment
Overcoming line broadening of labile protons and achieving high-resolution NMR spectra is crucial for the structural and conformational analysis of organic molecules. Recently, Ma et al. (Magn. Reson. Chem. 2024, 62, 198-207) demonstrated the effectiveness of 2,2,2-trifluoroacetic acid (TFA) in sharpening NMR signals for nitrogen-containing compounds which exhibit prototropic tautomerization or conformational isomerism using high molar ratio of [acids]/[solute] ~ 5 to 200. In this commentary, we provide an overview of earlier publications and highlight the extensive applications of TFA in enhancing NMR resolution across a variety of organic functional groups, with the use of very small ratios of [acids]/[solute] ~ 10<sup>-3</sup> to 10<sup>-2</sup>. The prospects for the unequivocal structure analysis using labile protons as the starting point will be analyzed.
Authors
- Pantelis Charisiadis (ORCID: https://orcid.org/0000-0001-7260-192X)
- Christina Papaemmanouil
- Andreas G. Tzakos (ORCID: https://orcid.org/0000-0001-6391-0288)
- Ioannis P. Gerothanassis (ORCID: https://orcid.org/0000-0002-3745-9902)
- Themistoklis Venianakis (ORCID: https://orcid.org/0000-0001-7932-9316)
- Alexandra Primikyri (ORCID: https://orcid.org/0000-0002-2500-5815)
- Michael G. Siskos (ORCID: https://orcid.org/0000-0003-0988-1142)
Institutions
- University of Ioannina (GR)
Publication Details
- Journal
- Magnetic Resonance in Chemistry
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/mrc.5499
- Citations
- 7
- Primary Topic
- Molecular spectroscopy and chirality
- Type
- article
- Field-Weighted Citation Impact
- 1.69