Knockdown of TREML2 Alleviates Neuropathological Hallmarks and Cognitive Deficiency in a Model of Sporadic Alzheimer’s Disease
This study offers the first in vivo evidence that TREML2 contributes to the pathogenesis of AD. Furthermore, this study also proves that inhibition of TREML2 signaling may represent a potential treatment strategy for this disease.
Authors
- Jingwen Qi (ORCID: https://orcid.org/0000-0003-1838-9061)
- Xinxin Fu (ORCID: https://orcid.org/0000-0001-9206-2265)
- Teng Jiang (ORCID: https://orcid.org/0000-0003-4170-1156)
- Zhi-Hang Huang (ORCID: https://orcid.org/0009-0001-1975-9573)
- Shiyao Wang (ORCID: https://orcid.org/0000-0003-4028-5269)
- Zhihuan Luo (ORCID: https://orcid.org/0000-0002-3616-7115)
- Yingdong Zhang
- Yan E
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s489474
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province