Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones
The SAR study confirmed a relationship between antimicrobial activity and the tested compounds. Molecular docking demonstrated that compounds <b>10</b>, <b>11</b>, <b>12</b>, <b>13</b>, and <b>14</b> exhibited significant binding energy, effectively interacting with the active sites of antimicrobial protein receptors. This consistent finding supports that these new compounds' practical and theoretical studies align regarding their antimicrobial activity.
Authors
- Sami A. Al‐Hussain (ORCID: https://orcid.org/0000-0002-4305-934X)
- Ameen A. Abu‐Hashem (ORCID: https://orcid.org/0000-0001-8557-2806)
Institutions
- Imam Mohammad ibn Saud Islamic University (SA)
- Jazan University (SA)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/ph17121632
- Citations
- 28
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 7.00
Funders
- National Research Centre