The pathogenic relationship between metabolic syndrome and rheumatoid arthritis activity

Metabolic syndrome (MetS) and its components often occur in patients with rheumatoid arthritis (RA). Both conditions, RA and MetS, share pro-inflammatory pathogenic mechanisms. The occurrence of MetS in patients with RA seems to be associated with higher disease activity and suboptimal response to treatment. In this review, we have presented the pathogenesis of MetS and its associations with metabolic disorders in RA. Screening for and managing MetS is necessary to reduce cardiovascular risk and improve prognosis in patients with RA.