Effect of platelet rich fibrin on post-operative sequelae following mandibular third molar surgery a prospective comparative study

<strong>Objectives:</strong> The purpose of this study is to estimate the effect of Platelet Rich Fibrin (PRF) on the control of post-operative sequalae i.e. Pain, Trismus, Swelling and Incidence of Alveolar Osteitis (AO) following mandibular third molar surgery <strong>Material and Methods: </strong>26 patients divided into two groups. Group I getting PRF after extraction of third molar while Group II did not get any PRF. Post-surgical Pain, Swelling, Trismus, Incidence of AO was evaluated. <strong>Results: </strong>It was found that Group II had greater pain scores than Group I assessed by VAS, with statistically significant greater score after 2 hours (<em>P</em>=0.0014) and 12 hours (<em>P</em>=0.0063). In case of swelling, Site II shown statistically significant difference in 7^th day (<em>P</em>=0.007), and 14^th day (<em>P</em>=0.04), Site III shown statistically significant difference in 3^rd day (<em>P</em>=0.005), 7^th day (<em>P</em>=0.03), and Site IV shown statistically significant difference in only in 3^rd day (<em>P</em>=0.004). Inter-incisal distance was higher for Group I than Group II, statistically significant on 7^th day (<em>P</em>=0.0069) and 14^th day (<em>P</em>=0.0008). This study did not find any incidence of AO in both groups <strong>Conclusions:</strong> PRF appears to be beneficial and effective in lowering postoperative sequalae in mandibular third molar surgery. PRF effectively decreases Pain, Swelling and Trismus when compared with case and control group. However, this study cannot comment on effectiveness of PRF on incidence of alveolar osteitis <strong>Received: 26 September 2024 </strong> <strong>Accepted: 31 October 2024 </strong> <strong>Published: 20 November 2024</strong>