The glycogene alterations and potential effects in esophageal squamous cell carcinoma
The expression of the POFUT1 and RPN1 glycogenes were upregulated, as determined by genomic copy number gain and proteomics analysis. The overexpression of POFUT1 or RPN1 was associated with poor prognosis in ESCC patients and affected the proliferation and metastasis of ESCC in vivo and in vitro. The overexpression of POFUT1 increased the overall fucosylation level and activated the Notch signaling pathway, which partially mediated POFUT1 induced pro-migration in ESCC. The regulation of malignant progression of ESCC by RPN1 may be related to the TNF signaling pathway, p53 signaling pathway, etc. CONCLUSIONS: Our study fills a gap in the study of abnormal glycogenes and highlights the potential role of the POFUT1/Notch axis in ESCC. Moreover, our study identifies POFUT1 and RPN1 as promising anticancer targets in ESCC.
Authors
- Tianyue Dong
- Yingzhen Gao
- Jinyan Chen (ORCID: https://orcid.org/0000-0003-4103-7056)
- Binbin Zou (ORCID: https://orcid.org/0000-0002-9467-8802)
- Yongping Cui (ORCID: https://orcid.org/0000-0001-9731-883X)
- Xuefei Feng
- Ling Zhang (ORCID: https://orcid.org/0000-0002-4100-0475)
- Yuanfang Zhai
- Xiaojuan Zhang (ORCID: https://orcid.org/0000-0002-9932-3939)
- Jianhong Lian (ORCID: https://orcid.org/0000-0002-6531-4524)
- Yanlin Guo (ORCID: https://orcid.org/0000-0003-0636-9223)
- Enwei Xu
Institutions
- Shanxi Medical University (CN)
- The Fifth People's Hospital of Anyang (CN)
- Shanxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1007/s00018-024-05534-3
- Citations
- 5
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Shanxi Scholarship Council of China
- Shanxi Province Science Foundation for Youths