Survival Outcomes with Regorafenib and/or Trifluridine/Tipiracil Sequencing to Rechallenge with Third-Line Regimens in Metastatic Colorectal Cancer: A Multicenter Retrospective Real-World Subgroup Comparison from the ReTrITA Study
This study suggests that rechallenge therapy may improve survival rates in the third-line treatment of mCRC, particularly if it is administered before sequential R/T treatment. This could allow for the extension of mCRC treatment choices until prospective studies are finished or randomised trials are performed.
Authors
- Emanuela Dell’Aquila (ORCID: https://orcid.org/0000-0002-7258-1364)
- Manuela Dettori
- Michele A. Basso (ORCID: https://orcid.org/0000-0001-8644-2966)
- Federica Mazzuca
- Maria Alessandra Calegari (ORCID: https://orcid.org/0000-0001-6856-2593)
- Ina Valeria Zurlo (ORCID: https://orcid.org/0000-0002-8876-4691)
- Adele Artemi
- Annunziato Anghelone (ORCID: https://orcid.org/0009-0003-2647-2110)
- Emanuela Lucci‐Cordisco (ORCID: https://orcid.org/0000-0002-6279-7604)
- Alessandro Bittoni (ORCID: https://orcid.org/0000-0002-4056-0067)
- Marta Ribelli
- Antonella Cosimati (ORCID: https://orcid.org/0000-0002-2636-3198)
- Marta Schirripa (ORCID: https://orcid.org/0000-0001-8316-4411)
- Jessica Lucchetti (ORCID: https://orcid.org/0000-0002-0262-535X)
- Maria Grazia Morandi
- Domenico Corsi (ORCID: https://orcid.org/0000-0002-5017-6704)
- Donatello Gemma
- Federica Zoratto (ORCID: https://orcid.org/0000-0001-8387-1968)
- Carlo Signorelli (ORCID: https://orcid.org/0000-0001-9710-4962)
- Alessandro Minelli (ORCID: https://orcid.org/0000-0003-3387-1489)
- Giulia Arrivi (ORCID: https://orcid.org/0000-0003-0541-415X)
- Lorenzo Angotti (ORCID: https://orcid.org/0009-0002-8378-2943)
- Fiorenza Santamaria (ORCID: https://orcid.org/0000-0002-1214-9342)
- Alessandra Emiliani (ORCID: https://orcid.org/0000-0001-8193-7599)
- Rosa Saltarelli
- Giovanni Luca Frassineti (ORCID: https://orcid.org/0000-0002-0277-5622)
- Alessandro Passardi (ORCID: https://orcid.org/0000-0002-7099-240X)
- Mario Giovanni Chilelli
- Cristina Morelli (ORCID: https://orcid.org/0000-0003-1797-7259)
- Emanuela Di Giacomo (ORCID: https://orcid.org/0009-0007-3006-3554)
Institutions
- University of Rome Tor Vergata (IT)
- Policlinico Umberto I (IT)
- Agostino Gemelli University Polyclinic (IT)
- Accademia di Belle Arti di Frosinone (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale San Paolo (IT)
- Ospedale di Belcolle (IT)
- Ospedale Santa Maria Goretti (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Vito Fazzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Current Oncology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/curroncol31120574
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.57