Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway
This study provides novel evidence that triolein exerts neuroprotective effects by inhibiting post-stroke inflammation through an autophagy-dependent mechanism. Moreover, the modulation of the AKT/mTOR signaling pathway appears to be integral to the neuroprotective efficacy of triolein. These findings elucidate potential therapeutic strategies for IS management and warrant further investigation.
Authors
- Lijuan Gu
- Daniel Smerin
- Xiaoxing Xiong (ORCID: https://orcid.org/0000-0001-6983-8547)
- Yonggang Zhang (ORCID: https://orcid.org/0000-0001-8027-245X)
- Yuntao Li (ORCID: https://orcid.org/0000-0001-8788-7537)
- Shuting Jiang
- Chaoqun Wang (ORCID: https://orcid.org/0000-0002-4649-5518)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1186/s10020-024-00995-5
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.97