Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments
the results obtained in this work show that the skeletal muscle functional unloading affects properties of FAPs in time-dependent manner: in atrophying skeletal muscle FAPs act as the sensors for the regulatory signals that may stimulate the metabolic and transcriptional reprogramming to preserve FAPs properties associated with maintenance of skeletal muscle homeostasis during unloading and in course of rehabilitation.
Authors
- Natalia A. Vilchinskaya (ORCID: https://orcid.org/0000-0002-8251-1271)
- Anna Aleksandrovna Kostareva (ORCID: https://orcid.org/0000-0002-9349-6257)
- Danila Bobkov (ORCID: https://orcid.org/0000-0002-0358-9266)
- Renata I. Dmitrieva (ORCID: https://orcid.org/0000-0002-3073-7914)
- Б. С. Шенкман (ORCID: https://orcid.org/0000-0002-2888-8502)
- Н. В. Хромова (ORCID: https://orcid.org/0000-0001-8348-6760)
- Margarita Sorokina
Institutions
- Karolinska Institutet (SE)
- Federal Almazov North-West Medical Research Centre (RU)
- Institute of Biomedical Problems (RU)
- Institute of Cytology (RU)
- Yandex (Russia) (RU)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1186/s13395-024-00362-2
- Citations
- 7
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Russian Science Foundation