Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in myocardial infarction patients
Increased perivascular fibrosis, fibroblast activation and vascular cellular transition in intramyocardial blood vessels of MI patients may contribute to MI development. Further increases of FAP expression and perivascular fibrosis, particularly in subacute-phase infarct cores, suggest MI itself exacerbates fibroblast activation and perivascular fibrosis, theoretically increasing reinfarction risk.
Authors
- Paul A.J. Krijnen (ORCID: https://orcid.org/0000-0002-5399-5617)
- G Sorrentino
- Hans W.M. Niessen (ORCID: https://orcid.org/0000-0001-9404-9822)
- Suat Şimşek (ORCID: https://orcid.org/0000-0002-0725-2468)
- Joris J. T. H. Roelofs (ORCID: https://orcid.org/0000-0001-9595-6571)
- Jiang Zhu (ORCID: https://orcid.org/0000-0003-0259-7157)
Institutions
- Northwest Hospital (US)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.jmccpl.2024.100275
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council
- Chinese Government Scholarship