Siwu decoction mitigates radiation-induced immune senescence by attenuating hematopoietic damage
SWD could slow down IR-induced immune senescence by improving hematopoietic and immunologic injury. SWD might reduce the inflammation level of BM hematopoietic microenvironment by acting on JAK/STAT signaling pathway, while the immune damage of mice was improved by affecting the differentiation of HSPCs. The remission of hematopoietic and immunologic senescence was further demonstrated at the overall level.
Authors
- Mingyue Huang
- Zhijie Bai (ORCID: https://orcid.org/0000-0003-2231-1320)
- Anping Ye
- Yanyan Zhang (ORCID: https://orcid.org/0000-0003-4596-1481)
- Haoyu Zhang (ORCID: https://orcid.org/0009-0000-5065-2937)
- Yi Ru
- Zeng-Chun Ma (ORCID: https://orcid.org/0000-0003-4543-1974)
- Yue Gao
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Beijing Radiation Center (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1186/s13020-024-01036-3
- Citations
- 3
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China