Effect of Ononis angustissima extract on the Aluminium alterations in intestinal histology

Ononis angustissima (Oa) is an endemic desert plant with medicinal qualities. Nevertheless, aluminum (Al) is a poisonous metal found in large quantities in nature. This investigation seeks to assess the impact of an aqueous Oa extract on adult rats intoxicated with AlCl3 at a dose of 100 mg/kg. The findings show that Al significantly reduced organ weight (p < 0.001), perturbed biochemical parameters, and caused histological changes in the intestine, including lymphoid tissue hyperplasia, villi erosion, and an increase in the number of goblet cells. However, treatment with the aqueous Oa extract exhibited anti-inflammatory effects, epithelial regeneration, and control of goblet cells. It is concluded that Al causes structural and metabolic alterations in intestinal tissue, but Oa has limited this damage.