Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma
This study successfully established reliable MR-based molecular imaging tools to visualize CD8<sup>+</sup> anti-tumor specific T-cell infiltration following partial cryoablation (pCryo) in murine tumor models. The study's significance lies in advancing our understanding of immune responses within induced cirrhosis and distinguishing between "hot" and "cold" tumor phenotypes. The findings not only build upon previous proof-of-principle data but also extend this technology to include different immune cell types in hepatocellular carcinoma. The study reveals that pCryo may exert specific effects on the tumor microenvironment, augmenting the anti-tumor immune response in immunogenic tumors while displaying a weaker local effect in non-immunogenic tumors.
Authors
- Julius Chapiro (ORCID: https://orcid.org/0000-0002-1984-2246)
- David C. Madoff (ORCID: https://orcid.org/0000-0003-3461-437X)
- James S. Duncan (ORCID: https://orcid.org/0000-0002-5167-9856)
- Jessica Gois Santana (ORCID: https://orcid.org/0000-0002-4370-5823)
- Daniel Coman (ORCID: https://orcid.org/0000-0002-6289-0817)
- David Nam (ORCID: https://orcid.org/0000-0002-4650-5691)
- Fahmeed Hyder (ORCID: https://orcid.org/0000-0001-7822-4002)
- Annabella Shewarega (ORCID: https://orcid.org/0000-0003-0663-3047)
Institutions
- Cedars-Sinai Medical Center (US)
- Yale University (US)
- Humboldt-Universität zu Berlin (DE)
- Society of Surgical Oncology (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101294
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Yale University
- Boston Scientific Corporation
- National Institutes of Health