Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice
Taken together, our results are the first to demonstrate that despite an extended recovery period, exposure to glyphosate elicits long-lasting pathological consequences. As glyphosate use continues to rise, more research is needed to elucidate the impact of this herbicide and its metabolites on the human brain, and their potential to contribute to dysfunctions observed in neurodegenerative diseases.
Authors
- Samantha K. Bartholomew (ORCID: https://orcid.org/0009-0009-4495-5187)
- Julie Turk
- Savannah Tallino (ORCID: https://orcid.org/0000-0003-3683-259X)
- Ritin Sharma (ORCID: https://orcid.org/0000-0001-8365-9916)
- Patrick Pirrotte (ORCID: https://orcid.org/0000-0003-1360-6039)
- Jessica M. Judd (ORCID: https://orcid.org/0000-0001-9993-6391)
- Wendy Winslow (ORCID: https://orcid.org/0000-0001-9641-4010)
- Khyatiben V. Pathak (ORCID: https://orcid.org/0000-0002-8050-0747)
- Rosario Velázquez (ORCID: https://orcid.org/0000-0003-2514-6818)
- Héctor León
Institutions
- Translational Genomics Research Institute (US)
- City of Hope (US)
- Arizona State University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12974-024-03290-6
- Citations
- 18
- Primary Topic
- Pesticide and Herbicide Environmental Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Arizona State University
- National Institutes of Health
- National Institute on Aging
- National Cancer Institute