Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency
These findings support the hypothesis that cells rely more on homologous recombination to repair proton-induced DNA damage compared to photon-induced DNA damage. As clinically applied hyperthermia enhances the therapeutic effect of photon irradiation by, among other factors, inducing homologous recombination deficiency, our results suggests that hyperthermia could be more effective in combination with proton irradiation than photon irradiation.
Authors
- Gerarda van de Kamp (ORCID: https://orcid.org/0000-0002-9483-4609)
- Roland Kanaar (ORCID: https://orcid.org/0000-0001-9364-8727)
- Marta Rovituso (ORCID: https://orcid.org/0009-0003-8269-1932)
- Jeroen Essers (ORCID: https://orcid.org/0000-0003-0605-7211)
- Tim Heemskerk (ORCID: https://orcid.org/0009-0001-4045-2189)
Institutions
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.ctro.2024.100898
- Citations
- 6
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Varian Medical Systems
- KWF Kankerbestrijding
- Oncode Institute