Hypothyroidism Promotes Microglia M1 Polarization by Inhibiting BDNF-Promoted PI3K-Akt Signaling Pathway
Our study demonstrated a sound conclusion that hypothyroidism promotes microglia M1 polarization by inhibiting BDNF expression in brain; BDNF could inhibit the M1 polarization of microglia by activating PI3K-Akt signaling pathway, which could serve as a promising therapeutic target for microglia-induced neurodegenerative or emotional disorders in future.
Authors
- De-Fa Zhu (ORCID: https://orcid.org/0000-0001-6600-0423)
- Haiwang Zhang (ORCID: https://orcid.org/0000-0001-6049-6392)
- Xian Wu (ORCID: https://orcid.org/0000-0003-1118-9710)
- Yi Dong (ORCID: https://orcid.org/0000-0002-0212-1477)
- Fen Wang (ORCID: https://orcid.org/0000-0002-4876-710X)
- Yuan Zhan
- Lang Lang (ORCID: https://orcid.org/0000-0003-3495-0146)
- Hao Yang (ORCID: https://orcid.org/0009-0007-7437-1815)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Ministry of Education (KN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1159/000542858
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- National Natural Science Foundation of China
- Anhui Medical University