Transcriptome sequencing-based study on the mechanism of action of Jintiange capsules in regulating synovial mesenchymal stem cells exosomal miRNA and articular chondrocytes mRNA for the treatment of osteoarthritis.
JTGs can improve the degeneration of joint cartilage and achieve the purpose of cartilage protection, which can be used for the treatment of OA. SMSCs-related miRNA expression profiles were significantly altered after the intervention with JTGs containing serum. The 9 co-differentially expressed genes may be the key targets for the efficacy of JTGs in the treatment of OA rats, which can be used for subsequent validation.
Authors
- Zou Junbo
- Xue Zhang (ORCID: https://orcid.org/0000-0001-8942-4333)
- Xiaofei Zhang (ORCID: https://orcid.org/0000-0002-4837-0188)
- P. Yuan (ORCID: https://orcid.org/0000-0001-7916-8823)
- Yajun Shi (ORCID: https://orcid.org/0000-0002-3682-7099)
- Chen Zhongying
Institutions
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20240927.004
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94