Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression <i>in Vitro</i>.
Our findings indicate the mechanism of action of indomethacin in mitigating OA progression, indicating that it can inactivate the PI3K/AKT/mTOR signaling pathway, thereby regulating inflammation, metabolism, apoptosis, and autophagy in chondrocytes, which attenuates the development of OA.
Authors
- Na Li (ORCID: https://orcid.org/0000-0002-2630-1149)
- Daniel J. Song (ORCID: https://orcid.org/0000-0002-2214-5986)
- Tengfei Wang (ORCID: https://orcid.org/0000-0002-1253-0514)
- Xin Zhao (ORCID: https://orcid.org/0009-0001-4641-5258)
- Zhen Meng (ORCID: https://orcid.org/0000-0003-0337-422X)
- Weiling Wang (ORCID: https://orcid.org/0000-0003-2095-4744)
- Bo Wang (ORCID: https://orcid.org/0009-0002-6995-6476)
Institutions
- Qingdao University (CN)
- Yuhuangding Hospital (CN)
- Zhangqiu City People's Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94