Moxibustion inhibits the macrophage M1 polarization toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B signaling pathway by regulating T-cell immunoglobulin and mucin-containing protein-3 in rheumatoid arthritis.
Moxibustion regulates the key target TIM-3 by acting on the Zusanli (ST36) and Shenshu (BL23) points, thereby inhibiting the M1 polarization of macrophages; that is, it inhibits the TLR4-MyD88-NF-κB signaling pathway, and finally achieves alleviation of pathological changes and anti-inflammatory effects.
Authors
- Wenbin Ma (ORCID: https://orcid.org/0000-0003-4800-7992)
- Xin Yang (ORCID: https://orcid.org/0000-0002-2832-9786)
- Yumei Zhong (ORCID: https://orcid.org/0000-0002-0374-2419)
- Kun Luo (ORCID: https://orcid.org/0000-0003-3835-8342)
- Haiyan Zhou (ORCID: https://orcid.org/0000-0003-1568-5287)
- Guo Yanding
- H U Danhui
- Linlin Zhang (ORCID: https://orcid.org/0000-0002-2644-4289)
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2024.06.009
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China