Bufei Huoxue capsule alleviates silicosis by inhibiting the activation of nucleotide-like receptor containing pyrin domain 3 inflammasome and macrophages polarization based on network pharmacology.
NOD-like receptor signaling is vital for BFHX's effects on silicosis. It exerts anti-pulmonary fibrosis effects by inhibiting pulmonary macrophage pyroptosis and polarization through NLRP3 inflammasome activation.
Authors
- Bong‐Sik Yun (ORCID: https://orcid.org/0000-0002-0594-8955)
- Jie Zhao (ORCID: https://orcid.org/0000-0003-1335-7175)
- Haiquan Li (ORCID: https://orcid.org/0000-0002-8049-0278)
- Xianmei Zhou
- Songquan Wang (ORCID: https://orcid.org/0000-0003-4382-9727)
- Hang Wenlu
- Zuo Shurun
- B U Chunlu
- Lin Wang (ORCID: https://orcid.org/0000-0003-3033-4792)
Institutions
- Jiangsu Normal University (CN)
- Xuzhou Medical College (CN)
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- Anhui Science and Technology University (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20240626.004
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University