[Megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and early-stage endometrial adenocarcinoma: a prospective study].
Metformin combined with MA may provide an effective option for fertility-sparing treatment of AEH and grade 1 stage IA EAC, and the clinical benefits of metformin for controlling MA-induced weight gain and promoting endometrial expressions of IGFBP-rP1 and p-AMPK while inhibiting p-Akt expression warrants further study.
Authors
- Danxia Chu
- Tianjiao Lai (ORCID: https://orcid.org/0000-0002-7191-4753)
- Haixia Qin (ORCID: https://orcid.org/0000-0002-9908-8940)
- Ruixia Guo (ORCID: https://orcid.org/0000-0002-8847-2488)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-1984-1136)
- Jing Bai (ORCID: https://orcid.org/0000-0002-7011-5909)
- Shuping Yan
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.11.01
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Recruitment Program of Global Experts