[Hepatic T cell subtypes and functional analysis among alveolar echinococcosis patients using single-cell RNA sequencing].
CD4<sup>+</sup> effector memory T cells and CD8<sup>+</sup> cytotoxic T cells are primary interacting cells in the liver specimens of AE patients. Reduced expression of Th2 cells and CD4<sup>+</sup> helper T cells contributes to an inhibitory immune microenvironment, which promotes immune evasion by <i>Echinococcus multilocularis</i>, and Th2 cells are significantly enriched in multiple cancer-associated pathways, which may be linked to the invasive growth of <i>E. multilocularis</i>.
Authors
- Xinwei Han (ORCID: https://orcid.org/0000-0003-4460-8619)
- Qiucheng Cai
- Liang Zhu (ORCID: https://orcid.org/0000-0003-3779-7853)
- Qingbi Zhang (ORCID: https://orcid.org/0000-0003-0416-2448)
- Zheng Hu (ORCID: https://orcid.org/0000-0001-9306-9442)
- Bin Li (ORCID: https://orcid.org/0009-0008-3791-0936)
- Xiaogang Wang (ORCID: https://orcid.org/0000-0002-7929-5889)
- Xiaobo Zhang (ORCID: https://orcid.org/0000-0003-4606-212X)
- Sheng Chen (ORCID: https://orcid.org/0000-0003-3526-7808)
- Weijuan Jia
- Xilin Wang (ORCID: https://orcid.org/0000-0002-5285-365X)
Institutions
- Qinghai University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-08
- DOI
- https://doi.org/10.16250/j.32.1915.2024172
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article