[Ferroptosis inducer Erastin inhibits proliferation of liver cancer cells <i>in vitro</i> by downregulating ACSL4].
ACSL4 level is significantly overexpressed in liver cancer. Erastin increases MDA contents and down-regulates ACSL4 expression, thereby promoting ferroptosis and inhibiting proliferation of liver cancer cells, and these effects can be reversed by Fer-1.
Authors
- Zihui Zhou (ORCID: https://orcid.org/0009-0000-3016-7096)
- Yi Tu (ORCID: https://orcid.org/0000-0002-2051-8806)
- Sing‐Han Huang (ORCID: https://orcid.org/0000-0003-0289-2260)
- Pan Zhao (ORCID: https://orcid.org/0000-0001-7579-9783)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Jian Tu (ORCID: https://orcid.org/0000-0002-5964-5634)
Institutions
- Guilin Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.11.09
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article