2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway.
HMA induced apoptosis in HepG2 cells, while inhibiting proliferation and invasion. The mechanism of HMA against HCC may be related to the SIRT1/p53 pathway.
Authors
- Taoyuan Zhang
- Lu Qiao (ORCID: https://orcid.org/0000-0002-9037-5927)
- Shuang Wei (ORCID: https://orcid.org/0000-0002-2319-4819)
- Zhu Xieying
Institutions
- People’s Hospital of Rizhao (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20230904.005
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00