<i>Hif-1α</i> ablation reduces the efficiency of NeuroD1 gene-based therapy and aggravates the brain damage following ischemic stroke
Our findings demonstrate that <i>Hif-1α</i> ablation from the nervous system is implicated in ischemic stroke pathogenesis mainly by increasing neuron cell death and inducing astrocytes as well as decreasing the efficiency of NeuroD1. These data support the idea that manipulating HIF-1α is a viable therapeutic for ischemic stroke.
Authors
- Javaria Sundus
- Ahmed Abdelsadik (ORCID: https://orcid.org/0000-0002-4782-6681)
- Nashwa Amin (ORCID: https://orcid.org/0000-0002-1918-4319)
- Alemayehu Hussein
- Marong Fang (ORCID: https://orcid.org/0000-0002-6636-4347)
- Abuelhassan Elshazly Younis (ORCID: https://orcid.org/0000-0001-7476-9320)
- Irum Naz Abbasi
- Yu Geng (ORCID: https://orcid.org/0000-0001-7615-7950)
- Bingxin Zhao
- Fei Wu (ORCID: https://orcid.org/0000-0001-5974-4029)
- Zongjie Shi (ORCID: https://orcid.org/0000-0002-1148-953X)
Institutions
- Children's Hospital of Zhejiang University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
- Aswan University (EG)
Publication Details
- Journal
- Expert Opinion on Drug Delivery
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1080/17425247.2024.2435458
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- National Natural Science Foundation of China