STING modulates HBV-related acute-on-chronic liver failure by mediating autophagy and macrophage polarization
Sting-induced autophagy exerts a protective effect on liver injury during the early stage. However, in later stages, STING may aggravate liver injury by shifting liver macrophage polarization to the M1 phenotype, thereby enhancing the inflammatory response.
Authors
- Futing Liu (ORCID: https://orcid.org/0000-0002-4495-520X)
- Wanlu Duan
- Hao Zhang (ORCID: https://orcid.org/0000-0002-5046-9785)
- Jianfei Li (ORCID: https://orcid.org/0000-0003-4289-8333)
- Qiang Zhou
- Qiyin Zong (ORCID: https://orcid.org/0009-0005-6981-2546)
- Teng Liang (ORCID: https://orcid.org/0000-0003-1991-1173)
- Liping Li (ORCID: https://orcid.org/0000-0001-9180-5987)
- Lei Jin (ORCID: https://orcid.org/0000-0002-7710-353X)
- Qin Wang (ORCID: https://orcid.org/0009-0004-3954-7879)
- Qian Liu (ORCID: https://orcid.org/0000-0001-5341-1290)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.imbio.2024.152860
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.48