Sphingosine 1-phosphate acts as proliferative and fibrotic cue in leiomyoma cells
These results, besides extending the knowledge on the molecular mechanism underlying uterine leiomyoma development and fibrosis, demonstrate the pathogenetic role of S1P in leiomyoma and support the rationale for targeting S1P signaling pathway as innovative potential treatment.
Authors
- Massimiliano Fambrini
- Margherita Rossi (ORCID: https://orcid.org/0000-0003-1412-9262)
- Maryam Raeispour (ORCID: https://orcid.org/0009-0002-3668-1648)
- Lucia Romeo (ORCID: https://orcid.org/0009-0000-2842-0654)
- Isabelle Seidita (ORCID: https://orcid.org/0000-0002-7777-1124)
- Felice Petraglia (ORCID: https://orcid.org/0000-0002-8851-625X)
- Pasquapina Ciarmela (ORCID: https://orcid.org/0000-0002-4400-3786)
- Chiara Donati (ORCID: https://orcid.org/0000-0003-2224-4199)
- Matteo Prisinzano (ORCID: https://orcid.org/0000-0002-0238-7101)
- Flavia Sorbi (ORCID: https://orcid.org/0000-0001-7277-6420)
- Caterina Bernacchioni (ORCID: https://orcid.org/0000-0002-1023-0067)
Institutions
- Marche Polytechnic University (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- F&S Science
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.xfss.2024.11.003
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Dipartimenti di Eccellenza
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Firenze
- Uniformed Services University of the Health Sciences