T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension
T<sub>FH</sub>/IL-21 axis amplified pulmonary vascular remodelling in HPH. This involved M2 macrophage polarization, PASMCs proliferation and pyroptosis. These data suggested that T<sub>FH</sub>/IL-21 axis may be a novel therapeutic target for the treatment of HPH.
Authors
- Huiling Yao
- Jie Huang (ORCID: https://orcid.org/0000-0001-7951-2217)
- Shaoze Zhang (ORCID: https://orcid.org/0000-0001-9387-2462)
- Huan Yang (ORCID: https://orcid.org/0000-0003-1808-4735)
- Cheng Li (ORCID: https://orcid.org/0000-0002-1766-1409)
- Hao Zhu (ORCID: https://orcid.org/0000-0002-6507-8904)
- Guang Li (ORCID: https://orcid.org/0000-0003-2993-7588)
- Pingping Liu (ORCID: https://orcid.org/0000-0003-4758-7630)
- Gang Jiang (ORCID: https://orcid.org/0000-0003-0563-3870)
- Aiguo Dai (ORCID: https://orcid.org/0000-0002-6517-8868)
- Yongliang Jiang (ORCID: https://orcid.org/0000-0003-4323-2584)
- Jun Zha
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Hunan Normal University (CN)
- Changsha Central Hospital (CN)
- Hunan Children's Hospital (CN)
- Hunan Provincial People's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12931-024-03058-9
- Citations
- 7
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.93