Modeling and optimization of culture media for recombinant Helicobacter pylori vaccine antigen HpaA
This study pioneers the statistical optimization of culture media to enhance rHpaA production, thereby supporting its large-scale application in <i>H. pylori</i> vaccines. Additionally, it highlights the advantages of the ANN-GA approach in bioprocess optimization.
Authors
- Ratna Tan
- Min Sun (ORCID: https://orcid.org/0000-0002-8528-0050)
- Kaiyun Liu (ORCID: https://orcid.org/0000-0003-1659-3894)
- Gang Guo (ORCID: https://orcid.org/0000-0002-4440-6366)
- Yu Liu (ORCID: https://orcid.org/0000-0002-2515-4431)
- Song Zhou (ORCID: https://orcid.org/0000-0003-0358-1309)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Xiumei Ni (ORCID: https://orcid.org/0000-0003-1231-4333)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fbioe.2024.1499940
- Citations
- 3
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- West China Hospital, Sichuan University