Loss of Sult1a1 reduces body weight and increases browning of white adipose tissue
Our results associate Sult1a1 deletion with a tendency for lower body weight through remodeling of white adipose tissue towards a brown phenotype. The presence of UCP1, the expression of an additional mitochondrial protein and increased respiratory capacity suggest browning of the subcutaneous adipose tissue depot of Sult1a1 KO mice.
Authors
- Bogdan Galusca (ORCID: https://orcid.org/0000-0002-0154-6924)
- Emmanuelle Meugnier (ORCID: https://orcid.org/0000-0002-2291-7691)
- Martin Klingenspor (ORCID: https://orcid.org/0000-0002-4502-6664)
- Bruno Estour
- Kevin Sebastiaan Hof (ORCID: https://orcid.org/0000-0002-4162-590X)
- Tania Sorg (ORCID: https://orcid.org/0000-0001-6974-4735)
- Hubert Vidal (ORCID: https://orcid.org/0000-0002-9467-0317)
- Natacha Germain (ORCID: https://orcid.org/0000-0001-6949-7244)
- Margherita Springer (ORCID: https://orcid.org/0000-0002-2361-4940)
- Jörg Hager (ORCID: https://orcid.org/0000-0002-6634-9294)
- Benoit Petit‐Demoulière (ORCID: https://orcid.org/0000-0001-5616-7692)
- Katharina Schnabl (ORCID: https://orcid.org/0000-0001-7732-8934)
- Marie‐France Champy
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Hospices Civils de Lyon (FR)
- Nestlé (Switzerland) (CH)
- Phénotypage et ingénierie précliniques des systèmes d’organismes modèles (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
- Else Kröner-Fresenius-Stiftung (DE)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Institut National des Sciences Appliquées de Lyon (FR)
- Technical University of Munich (DE)
- Université de Strasbourg (FR)
- Université Jean Monnet (FR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fendo.2024.1448107
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- University of Bern