Calcium sensing receptor regulate claudin-14 via PKA-STAT3 pathway in rat model of nephrolithiasis
The results of our study indicate that calcium oxalate crystals induce the activation of the pro-stone pathway of CaSR. That is, activated CaSR regulates claudin-14 levels via the PKA-STAT3 pathway, which further promotes calcium salt stone formation. The role of CaSR in the regulation of stone homeostasis is further enriched.
Authors
- Liying Zheng (ORCID: https://orcid.org/0000-0003-2850-4668)
- Jun Zou (ORCID: https://orcid.org/0000-0003-2443-3516)
- Junrong Zou (ORCID: https://orcid.org/0000-0003-4409-5294)
- Wei Li (ORCID: https://orcid.org/0000-0002-1694-5952)
- Qi Chen (ORCID: https://orcid.org/0000-0001-6353-9589)
- Tao Chen (ORCID: https://orcid.org/0000-0003-4565-5548)
- Biao Qian
- Peiyue Luo
- Le Cheng
Institutions
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fphar.2024.1477122
- Citations
- 5
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.24