Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke
Our results demonstrated that the combined treatment extended the neurorestorative efficacy of morroniside, reduced infarct size, enhanced neuronal excitability and accelerated sensorimotor function recovery. This therapeutic approach may emerge as a potential clinical intervention for chronic ischemic stroke.
Authors
- Yufeng Wang (ORCID: https://orcid.org/0000-0003-1417-1460)
- Jianguo Xing (ORCID: https://orcid.org/0000-0002-0411-254X)
- Xin Tian (ORCID: https://orcid.org/0000-0003-0392-6362)
- Wen Wang (ORCID: https://orcid.org/0000-0003-4120-0773)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-7348-809X)
- Yanxi Chen (ORCID: https://orcid.org/0000-0002-4021-6020)
- Zhidong Xu
- Yifu Ma
- Zixin Zhu
- Ruifang Zheng
- Fangling Sun (ORCID: https://orcid.org/0009-0002-2455-2750)
- Wenrong Zheng
Institutions
- Capital Medical University (CN)
- Hebei University of Science and Technology (CN)
- Beijing Geriatric Hospital (CN)
- Xinjiang Institute of Materia Medica (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fphar.2024.1457309
- Citations
- 2
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- National Natural Science Foundation of China