Double-blinded, randomized tolerance study of a biologically enhanced Nanogel with endothelin-1 and bradykinin receptor antagonist peptides via intra-articular injection for osteoarthritis treatment in horses
Injections of the expected therapeutic dose of functionalized nanogel in healthy joints induced a mild transient inflammatory response in the joint. Three injections of the trial dose at one-week intervals and injection of thrice the trial dose induce a mildly greater inflammation without harmful effects on joints. Functionalized nanogels are well tolerated prospects for the treatment of osteoarthritis in horses. Their beneficial effects on arthritic joints have yet to be evaluated to determine their therapeutic potential.
Authors
- Sandrine Jacquet (ORCID: https://orcid.org/0000-0002-9609-0690)
- Magali Demoor (ORCID: https://orcid.org/0000-0002-8975-7055)
- Aurélie Cullier (ORCID: https://orcid.org/0000-0002-0521-1232)
- Araceli Ac Garcia
- Seng Manivong
- Xavier Banquy (ORCID: https://orcid.org/0000-0002-3342-3179)
- Florence Legendre (ORCID: https://orcid.org/0000-0002-9951-1585)
- Florina Moldovan (ORCID: https://orcid.org/0000-0002-3028-672X)
- Frédéric Cassé (ORCID: https://orcid.org/0000-0001-7991-6123)
- Pierré Sirois
- Philippe Galéra (ORCID: https://orcid.org/0000-0002-7797-2284)
- Gaëlle Roullin (ORCID: https://orcid.org/0000-0002-0790-5246)
- Lélia Bertoni (ORCID: https://orcid.org/0000-0001-6367-3040)
- Fabrice Audigié
- Antoinette Terlinden
Institutions
- École Nationale Vétérinaire d'Alfort (FR)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Normandie Université (FR)
- Université Laval (CA)
- Biologie, Génétique et Thérapies ostéoArticulaires et Respiratoires
- Ho Chi Minh City University of Technology (VN)
- Université de Montréal (CA)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12917-024-04352-w
- Citations
- 3
- Primary Topic
- Veterinary Equine Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Arthritis Society
- European Commission
- Région Normandie
- European Regional Development Fund
- European Social Fund