The paracetamol metabolite N‐acetyl‐4‐benzoquinoneimine (NAPQI) prevents modulation of K<sub>V</sub>7 channels via G‐protein coupled receptors by interference with PIP<sub>2</sub> and Ca<sup>2+</sup> sensitivity
NAPQI targets the three-cysteine motif in the S2-S3 linker of K<sub>V</sub>7.2 channels to counteract the signalling cascades employed by inflammatory mediators that inhibit these channels. In sensory neurons, this abolishes the closure of K<sub>V</sub>7 channels by the inflammatory soup. This mechanism is likely involved in the alleviation of inflammatory pain by paracetamol.
Authors
- Klaus Schicker (ORCID: https://orcid.org/0000-0002-3068-7830)
- Stefan Boehm (ORCID: https://orcid.org/0000-0002-0205-2459)
- Isabella Salzer (ORCID: https://orcid.org/0000-0003-1049-377X)
- Oliver Kudlacek (ORCID: https://orcid.org/0000-0002-3086-8551)
- Jae‐Won Yang (ORCID: https://orcid.org/0000-0001-8928-0130)
- Thomas Losgott
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1111/bph.17419
- Citations
- 5
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Austrian Science Fund