Differential predictive value of resident memory CD8 <sup>+</sup> T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy
This study highlights the non-equivalence of T<sub>RM</sub> subpopulations. The population of T<sub>RM</sub> co-expressing CD103 and CD49a appears to be the most functional and has the most significant capacity for predicting response to immunotherapy in multivariate analysis in patients with NSCLC.
Authors
- Hang‐Phuong Pham (ORCID: https://orcid.org/0000-0002-7896-7401)
- Jennifer Arrondeau
- Pascaline Boudou‐Rouquette (ORCID: https://orcid.org/0000-0002-4860-305X)
- Isabelle Cremer (ORCID: https://orcid.org/0000-0002-0963-1031)
- Thi Tran (ORCID: https://orcid.org/0000-0003-4012-5898)
- Éric Tartour (ORCID: https://orcid.org/0000-0002-7323-468X)
- Sébastien Mella (ORCID: https://orcid.org/0000-0002-8679-5718)
- Joséphine Pineau (ORCID: https://orcid.org/0000-0002-7494-5627)
- Jonathan Ulmer (ORCID: https://orcid.org/0000-0002-5078-4822)
- Milena Hasan (ORCID: https://orcid.org/0000-0002-0879-7099)
- Louis-Victorien Vieillard
- Stéphanie Corgnac (ORCID: https://orcid.org/0000-0002-3014-9178)
- Valentina Libri (ORCID: https://orcid.org/0000-0002-2080-1089)
- Elizabeth Fabre (ORCID: https://orcid.org/0000-0002-1244-873X)
- Nadège Gruel (ORCID: https://orcid.org/0000-0001-6915-8082)
- Hortense de Saint Basile
- Valentin Quiniou (ORCID: https://orcid.org/0000-0002-0792-341X)
- Sixtine De Percin (ORCID: https://orcid.org/0000-0001-5773-0205)
- Marie Wislez (ORCID: https://orcid.org/0000-0001-7518-7859)
- Jean-Philippe Villemin (ORCID: https://orcid.org/0000-0002-1838-5880)
- Karen Leroy (ORCID: https://orcid.org/0000-0002-4379-0140)
- Léa Paolini (ORCID: https://orcid.org/0000-0001-8041-4761)
- Hélène Blons (ORCID: https://orcid.org/0000-0002-0572-8426)
- Fathia Mami‐Chouaib (ORCID: https://orcid.org/0000-0001-9685-6011)
- François Goldwasser (ORCID: https://orcid.org/0000-0002-7128-6128)
- Laure Gibault (ORCID: https://orcid.org/0000-0002-0791-074X)
- Aziza Caidi
- Diane Damotte (ORCID: https://orcid.org/0000-0001-5355-3045)
- Ludger Johannes (ORCID: https://orcid.org/0000-0002-2168-0004)
- Pierre Barennes (ORCID: https://orcid.org/0000-0002-3017-0719)
- Alain Gey (ORCID: https://orcid.org/0000-0002-3821-0674)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Patrice Ravel
Institutions
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Paris Cardiovascular Research Center (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009440
- Citations
- 16
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Fondation ARC pour la Recherche sur le Cancer
- Ligue Contre le Cancer
- Institut National Du Cancer
- Labex Immuno-Oncology