Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy
Th22 cells secrete IL-22 after passing through the BBB into the hippocampus and promote the transformation of homeostatic microglia into reactive microglia, which induces an inflammatory response, exacerbates learning and memory impairment and cognitive deficits, and contributes to and accelerates the development of DE.
Authors
- Shuhan Lv (ORCID: https://orcid.org/0009-0003-3392-7881)
- Xuezheng Liu (ORCID: https://orcid.org/0009-0004-2855-2752)
- W. Liu (ORCID: https://orcid.org/0009-0006-4336-8923)
- Yan Wang (ORCID: https://orcid.org/0000-0001-8425-5892)
- Wenqiang Liu (ORCID: https://orcid.org/0000-0002-2323-7962)
- Hong Yu (ORCID: https://orcid.org/0000-0003-4164-4673)
- Shengxue Yu
- Junqi Li (ORCID: https://orcid.org/0000-0003-3457-4099)
- Zhongfu Zuo (ORCID: https://orcid.org/0000-0003-2466-8956)
- Jianqing Ding (ORCID: https://orcid.org/0009-0008-6117-350X)
- Tie-Feng Yao
- Yufei Wang (ORCID: https://orcid.org/0009-0000-6337-5211)
Institutions
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Acta Diabetologica
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1007/s00592-024-02384-0
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.48