Identification of Coumarin-Chalcone and Coumarin-Pyrazoline Derivatives as Novel Anti-Toxoplasma gondii Agents
This study highlights the potential of coumarin-based hybrids as anti-<i>T. gondii</i> agents. The findings should contribute to the growing arsenal of small molecules against <i>T. gondii</i> and underscore the value of molecular hybridization in drug design. Further studies to elucidate these compounds' mechanism of action and in vivo efficacy are warranted to fully realize their potential as anti-parasitic agents.
Authors
- Urban Bren (ORCID: https://orcid.org/0000-0002-8806-3019)
- Manal S. Ebaid (ORCID: https://orcid.org/0000-0003-1222-5816)
- Justyna Gatkowska (ORCID: https://orcid.org/0000-0002-0559-1706)
- Jarosław Dziadek (ORCID: https://orcid.org/0000-0003-1427-884X)
- Veronika Furlan (ORCID: https://orcid.org/0000-0003-1005-008X)
- Wagdy M. Eldehna (ORCID: https://orcid.org/0000-0001-6996-4017)
- Ahmed Sabt (ORCID: https://orcid.org/0000-0001-6976-0196)
- Hoda Atef Abdelsattar Ibrahim (ORCID: https://orcid.org/0000-0001-5399-8861)
- Maciej Chyb (ORCID: https://orcid.org/0000-0002-3964-671X)
Institutions
- Northern Border University (SA)
- University of Primorska (SI)
- Kafrelsheikh University (EG)
- Cairo University (EG)
- Pharos University in Alexandria (EG)
- University of Łódź (PL)
- University of Maribor (SI)
- Institute for Environmental Protection and Sensors (SI)
- National Research Centre (EG)
- Institute of Medical Biology (SG)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s495089
- Citations
- 3
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Northern Border University