Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modeling
The established PK/PD cutoffs, when used alongside the wild-type bacterial epidemiological cutoff, can aid in setting clinical breakpoints for oxytetracycline, supporting effective antimicrobial therapy in cattle and accounting for age-related pharmacokinetic differences.
Authors
- P. Lees (ORCID: https://orcid.org/0000-0002-8966-3737)
- Ludovic Pelligand (ORCID: https://orcid.org/0000-0001-6005-1975)
- Ronette Gehring (ORCID: https://orcid.org/0000-0002-1329-201X)
- Esther A. Winter (ORCID: https://orcid.org/0009-0002-3022-7727)
- Aneliya Milanova (ORCID: https://orcid.org/0000-0002-6876-9436)
- Pierre-Louis Toutain
Institutions
- Royal Veterinary College (GB)
- Trakia University (BG)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Utrecht University (NL)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fmicb.2024.1498219
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00