Understanding the toxicological effects of TiO2 nanoparticles extracted from sunscreens on human keratinocytes and skin explants
This study shows the feasibility of extracting nanoparticles from personal care products such as sunscreens to obtain relevant forms to model real-life exposure scenarios. Overall, sunscreen-extracted nanoparticles were found to be less toxic compared to pristine equivalents but retarded wound-edge migration more significantly. Skin explant cultures provide a more realistic alternative to monolayer cell cultures, although the differential outcomes between the models need more in-depth evaluation.
Authors
- Archana Gautam (ORCID: https://orcid.org/0000-0003-1463-7435)
- Kee Woei Ng (ORCID: https://orcid.org/0000-0002-7276-3563)
- Magdiel Inggrid Setyawati (ORCID: https://orcid.org/0000-0002-3221-077X)
- Ee Cherk Cheong (ORCID: https://orcid.org/0000-0002-4897-4029)
- Sunil S. Adav (ORCID: https://orcid.org/0000-0002-8559-4885)
- Darien Yu De Kwek (ORCID: https://orcid.org/0000-0002-4296-5279)
Institutions
- National Skin Centre (SG)
- Nanyang Technological University (SG)
- Tan Tock Seng Hospital (SG)
- Water Research Institute (SK)
- A*STAR Graduate Academy (SG)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12989-024-00610-9
- Citations
- 10
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministry of Education - Singapore
- Nanyang Technological University