SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting
These data highlight the combination of NE transporter blockade and selective D3 activation in pro-cognitive action without psychostimulant-like side effect liability. The absence of DA transporter blockade and non-selective dopaminergic activation are beneficial properties of SK609 that differentiates it from the traditional pro-cognitive psychostimulants.
Authors
- Christopher P. Knapp (ORCID: https://orcid.org/0000-0003-1066-6255)
- Sandhya Kortagere (ORCID: https://orcid.org/0000-0002-3532-8669)
- Brooke Fallon
- Stan Floresco (ORCID: https://orcid.org/0000-0002-5633-243X)
- Rachel L. Navarra (ORCID: https://orcid.org/0000-0002-4893-5468)
- Barry D. Waterhouse (ORCID: https://orcid.org/0000-0002-2086-4290)
Institutions
- University of British Columbia (CA)
- Rowan University (US)
- Drexel University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1007/s00213-024-06727-1
- Citations
- 2
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- U.S. Department of Defense
- New Jersey Commission on Brain Injury Research
- Osteopathic Heritage Foundation
- Rowan University