Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model
Despite the pronounced infection in the surrounding tissue, only few bacteria were detected on the surface of the steel implants. This is evident from the minimal findings by SEM before sonication, as well as the very low CFU counts and DNA copies in the sonicate. Sonication did not show variable effectiveness, indicating it is a valuable addition to, but not a replacement for biopsy cultures in cases of implant-associated infections with low-virulence microorganisms.
Authors
- Caroline Krogh Søgaard (ORCID: https://orcid.org/0000-0002-9528-2244)
- Alberto Díez-Sánchez (ORCID: https://orcid.org/0000-0001-5146-3089)
- Erik Thorvaldsen Sandbakken (ORCID: https://orcid.org/0000-0001-7947-5460)
- Eivind Witsø (ORCID: https://orcid.org/0000-0002-9616-1014)
- Tina S Wik (ORCID: https://orcid.org/0000-0001-7317-5475)
- Erling Høyer
- Linh Hoang (ORCID: https://orcid.org/0000-0001-8430-5722)
- Kåre Bergh
Institutions
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s13018-024-05309-3
- Citations
- 4
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- St. Olavs Hospital Universitetssykehuset i Trondheim