Left Anterior Descending Nonculprit Lesions and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction
Of the 4,041 subjects in COMPLETE, 1,666 patients had a proximal/mid-LAD NCL (41.2%). The first coprimary outcome occurred in 8.5% (2.9%/y) of patients with a proximal/mid-LAD NCL vs 9.9% (3.4%/y) in those without (adjusted HR: 0.83; 95% CI: 0.67-1.03). Complete revascularization had a similar benefit in reducing the first coprimary outcome for patients with a proximal/mid-LAD NCL (7.7% vs 9.2%; HR: 0.85; 95% CI: 0.61-1.18) and those without (8.0% vs 11.9%; HR: 0.65; 95% CI: 0.50-0.86), with no differential treatment effect (interaction P = 0.235) CONCLUSIONS: Among patients presenting with STEMI and multivessel CAD, those with a proximal/mid-LAD NCL had similar event rates to those without. The benefit of complete revascularization between the groups was similar, with no evidence of heterogeneity.
Authors
- John A. Cairns (ORCID: https://orcid.org/0000-0001-8875-8841)
- Matthias Bossard (ORCID: https://orcid.org/0000-0002-1587-2819)
- Jean‐François Tanguay (ORCID: https://orcid.org/0000-0003-1057-0528)
- Roxana Mehran (ORCID: https://orcid.org/0000-0002-5546-262X)
- Sunil V. Rao (ORCID: https://orcid.org/0000-0003-2914-0894)
- Kevin R. Bainey (ORCID: https://orcid.org/0000-0002-5458-4617)
- Warren J. Cantor (ORCID: https://orcid.org/0000-0002-7715-6746)
- Brian McGrath
- Helen Nguyen (ORCID: https://orcid.org/0000-0002-5285-1507)
- Robert F. Storey (ORCID: https://orcid.org/0000-0002-6677-6229)
- Érick Schampaert (ORCID: https://orcid.org/0000-0002-7607-1214)
- Vincenzo Guiducci
- Thenmozhi Mani (ORCID: https://orcid.org/0000-0002-3932-5625)
- Shahar Lavi (ORCID: https://orcid.org/0000-0002-6105-8084)
- Peter V. Johnston (ORCID: https://orcid.org/0000-0002-4258-6981)
- Hahn Hoe Kim
- Gianluca Calogero Campo (ORCID: https://orcid.org/0000-0002-5150-188X)
- David Wood (ORCID: https://orcid.org/0000-0001-5117-2353)
- Raúl Moreno (ORCID: https://orcid.org/0000-0001-7179-1426)
- Natalia Pinilla‐Echeverri (ORCID: https://orcid.org/0000-0001-7784-0348)
- Shamir R Mehta
- Vladimír Džavík
- Tej Sheth (ORCID: https://orcid.org/0009-0001-4651-8310)
Institutions
- Western University (CA)
- University Health Network (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- University of Toronto (CA)
- University of Ferrara (IT)
- Cardiovascular Institute of the South (US)
- Montreal Heart Institute (CA)
- Hospital Universitario La Paz (ES)
- London Health Sciences Centre (CA)
- Southlake Regional Health Center (CA)
- Population Health Research Institute (CA)
- St Mary's Hospital Centre (CA)
- NYU Langone Health (US)
- Mount Sinai Hospital (US)
- Santa Maria Nuova Hospital (IT)
- Luzerner Kantonsspital (CH)
- Arcispedale Sant'Anna (IT)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Johns Hopkins Hospital (US)
- Universidad Autónoma de Madrid (ES)
- Université de Montréal (CA)
- Hamilton Health Sciences (CA)
- University of Sheffield (GB)
- McMaster University (CA)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JACC: Cardiovascular Interventions
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.jcin.2024.09.004
- Citations
- 2
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- AstraZeneca Canada
- Boston Scientific Corporation
- Canadian Institutes of Health Research