Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
Among participants with chronic HBV infection who had virologic suppression with NA therapy, treatment with xalnesiran plus an immunomodulator resulted in HBsAg loss at 24 weeks after the end of treatment in a substantial percentage of participants. Grade 3 or 4 adverse events were not uncommon. (Funded by F. Hoffmann-La Roche; Piranga ClinicalTrials.gov number, NCT04225715.).
Authors
- Ruchi Upmanyu
- Tarik Asselah (ORCID: https://orcid.org/0000-0002-0024-0595)
- Wan‐Long Chuang (ORCID: https://orcid.org/0000-0002-2376-421X)
- Rémi Kazma
- Luís Morano (ORCID: https://orcid.org/0000-0002-0560-3260)
- Maria Teresa Catanese (ORCID: https://orcid.org/0000-0002-0401-2418)
- Cong Cheng (ORCID: https://orcid.org/0000-0003-4391-5027)
- Anchalee Avihingsanon (ORCID: https://orcid.org/0000-0003-3222-9611)
- Qingyan Bo
- Avinash S. Patil (ORCID: https://orcid.org/0000-0002-8617-150X)
- Katerina Glavini (ORCID: https://orcid.org/0000-0001-6789-8781)
- Jinlin Hou (ORCID: https://orcid.org/0000-0001-8230-8583)
- Filippo Canducci (ORCID: https://orcid.org/0000-0002-5637-6205)
- Sheng‐Shun Yang
- Jia‐Horng Kao (ORCID: https://orcid.org/0000-0002-2442-7952)
- Cheng‐Yuan Peng (ORCID: https://orcid.org/0000-0001-9030-6086)
- Xieer Liang (ORCID: https://orcid.org/0000-0002-0862-3291)
- Wei‐Wen Su (ORCID: https://orcid.org/0000-0001-5554-5938)
- Wenhong Zhang (ORCID: https://orcid.org/0000-0002-9165-3212)
- Cynthia Wat (ORCID: https://orcid.org/0000-0003-3991-999X)
- Vedran Pavlovic (ORCID: https://orcid.org/0000-0002-9475-7201)
- Miriam Triyatni
- Bernadette Surujbally (ORCID: https://orcid.org/0000-0002-3021-0821)
- Apinya Leerapun (ORCID: https://orcid.org/0000-0001-7951-3359)
- Farouk Chughlay
- Priyanka Kakrana
- Rui Hua (ORCID: https://orcid.org/0000-0001-7507-6155)
- Dong Joon Kim (ORCID: https://orcid.org/0000-0002-5792-1500)
- Hong Tang (ORCID: https://orcid.org/0000-0003-3912-2067)
- Qing Xie (ORCID: https://orcid.org/0000-0002-3298-1072)
- Yan Huang (ORCID: https://orcid.org/0000-0002-4747-3740)
- Ethan Chen (ORCID: https://orcid.org/0000-0003-1765-8290)
- Sudip Das (ORCID: https://orcid.org/0000-0003-3696-754X)
- Edward Gane
- Man-Fung Yuen
- Nelson Guerreiro
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1056/nejmoa2405485
- Citations
- 62
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 23.97
Funders
- F. Hoffmann-La Roche
- Genentech