Acute Eosinophilic Granulomatous Tubulointerstitial Nephritis in a Patient Receiving Combination Treatment with Three Drugs
We herein report a 69-year-old man with acute kidney injury who required dialysis after receiving a combination of three drug-induced lymphocyte stimulation test-positive drugs. A kidney biopsy showed tubulointerstitial nephritis with severe eosinophilic infiltration and numerous granuloma formations. Acute eosinophilic granulomatous tubulointerstitial nephritis was diagnosed. Eosinophilic granulomatosis with polyangiitis was ruled out because there was no evidence of vasculitis or serum antineutrophilic cytoplasmic antibody and no history of allergy. No clinical findings were suggestive of sarcoidosis. Based on the above findings, the disease was considered to be induced by these three drugs. The renal function was normalized with glucocorticoid treatment.
Authors
- Masatoshi Yoshimoto
- Yoshifumi Ubara (ORCID: https://orcid.org/0000-0003-2322-8203)
- Naoki Sawa (ORCID: https://orcid.org/0000-0003-2092-4094)
- Hiroki Mizuno (ORCID: https://orcid.org/0000-0003-4187-1067)
- Kei Kono (ORCID: https://orcid.org/0000-0002-9918-844X)
- Yutaka Yamaguchi (ORCID: https://orcid.org/0000-0002-4907-3388)
- Masayuki Yamanouchi (ORCID: https://orcid.org/0000-0003-3264-9691)
- Keiichi Kinowaki (ORCID: https://orcid.org/0000-0001-7915-9177)
- Takehiko Wada (ORCID: https://orcid.org/0000-0002-1231-2656)
- Kenichi Ohashi (ORCID: https://orcid.org/0000-0003-1836-1763)
- Yuki Oba (ORCID: https://orcid.org/0000-0002-1494-3291)
- Noriko Inoue
- Tatsuya Suwabe (ORCID: https://orcid.org/0000-0003-0825-2512)
- Akinari Sekine (ORCID: https://orcid.org/0000-0001-7326-4988)
- Eiko Hasegawa
- Kiho Tanaka
- Shigekazu Kurihara
Institutions
- Tokyo Medical and Dental University (JP)
- Toranomon Hospital (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-12-04
- DOI
- https://doi.org/10.2169/internalmedicine.4518-24
- Citations
- 2
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.65